Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice

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• 作者：You-Liang Hsieh^a ; Marthandam Asokan Shibu^b ; Chong-Kuei Lii^c ; Vijaya Padma Viswanadha^d ; Yi-Lin Lin^b ; Chao-Hung Lai^e ; Yu-Feng Chen^e ; Kuan-Ho Lin^f ; Wei-Wen Kuo^g ; ¹ ; Chih-Yang Huang^a ; ^b ; ^h ; ^{cyhuang@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cardiomyopathy ; Obesity ; Andrographis paniculata ; Cardiac remodeling
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：4 November 2016
• 年：2016
• 卷：192
• 期：Complete
• 页码：170-177
• 全文大小：2566 K

文摘

Andrographis paniculata (Burm. f.) Nees (Acanthaceae) has a considerable medicinal reputation in most parts of Asia as a potent medicine in the treatment of Endocrine disorders, inflammation and hypertension.

Aim of the study

Water extract of A. paniculata and its active constituent andrographolide are known to possess anti-inflammatory and anti-apoptotic effects. Our aim is to identify whether A. paniculata extract could protect myocardial damage in high-fat diet induced obese mice.

Materials and Methods

The test mice were divided into three groups fed either with normal chow or with high fat diet (obese) or with high fat diet treated with A. paniculata extract (2 g/kg/day, through gavage, for a week).

Results

We found that the myocardial inflammation pathway related proteins were increased in the obese mouse which potentially contributes to cardiac hypertrophy and myocardial apoptosis. But feeding with A. paniculata extract showed significant inhibition on the effects of high fat diet.

Conclusion

Our study strongly suggests that supplementation of A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.