Neoadjuvant Chemotherapy With Docetaxel-Cisplatin in Patients With Stage III N2 Non-Small-Cell Lung Cancer

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• 作者：Wei-Yu Liao¹ ; Jin-Hsin Chen² ; Muzo Wu¹ ; Jin-Yuan Shih¹ ; Kuan-Yuh Chen¹ ; Chao-Chi Ho¹ ; James Chih-Hsin Yang³ ; Chong-Jen Yu¹ ; ^{jefferycjyu@ntu.edu.tw}
• 关键词：Cisplatin ; Docetaxel ; Neoadjuvant chemotherapy ; Non-small-cell lung cancer
• 刊名：Clinical Lung Cancer
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：14
• 期：4
• 页码：418-424
• 全文大小：433 K

文摘

Introduction

To assess the efficacy and potential prognostic factors of patients with stage III N2 non-small-cell lung cancer (NSCLC) treated with neoadjuvant docetaxel-cisplatin (DP) chemotherapy followed by surgical resection.

Methods

Sixty-two patients with NSCLC treated with DP as neoadjuvant chemotherapy between November 2003 and December 2009 were identified and reviewed in this study. Tumor response, survival, and clinicopathologic data were collected retrospectively. The time to event was analyzed by fitting Cox proportional hazards models.

Results

Fifty-eight (94 % ) of 62 patients eventually underwent surgical resection after DP. The overall clinical response rate to induction DP chemotherapy was 42 % . Patients with squamous cell carcinoma (SCC) histology were more likely to response to the DP regimen than those with adenocarcinoma histology (68 % vs. 33 % , P = .006). With a median follow-up of 82.4 months among the 58 patients, there were 41 (71 % ) tumor relapses and 27 (47 % ) deaths. The median event-free survival was 27.5 months (95 % CI, 22.3-32.7 months), and the median overall survival was 66.7 months (95 % CI, 35.1-98.3 months). In multivariate analysis, when fitting the Cox proportional hazards model, SCC histology (hazard ratio [HR] 0.234 [95 % CI, 0.098-0.560]; P = .001) and mediastinal downstaging to N0 (HR 0.451 [95 % CI, 0.226-0.898]; P = .024) were independent predictors of better event-free survival.

Conclusions

Neoadjuvant chemotherapy with the DP regimen is both active and well tolerated in patients with stage III N2 NSCLC. SCC histology predicted a better treatment response and survival outcome than adenocarcinoma histology in this patient group. Further investigation of combined-modality treatment is warranted to improve survival in the adenocarcinoma subset of stage III N2 NSCLC.