The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention

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• 作者：Sang Hui Chu ; Ji-Hye Park ; Mi Kyung Lee ; Yoonsuk Jekal ; Ki Yong Ahn ; Jae Youn Chung ; Dong Hoon Lee ; Eun Sung Kim ; Masayo Naruse ; Jee-Aee Im ; Deok Kong ; Choon Hee Chung ; Ji Won Lee ; Kyong-Mee Chung ; Young-Bum Kim ; Justin Y. Jeon
• 关键词：PTX3 ; pentraxin 3 ; HOMA-IR ; homeostasis model assessment of insulin resistance ; OGTT ; oral glucose tolerance test ; WC ; waist circumference ; SAT ; subcutaneous adipose tissue ; VAT ; visceral adipose tissue ; PI3K ; phosphatidylinositol 3-kinase
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 出版时间：9 October, 2012
• 年：2012
• 卷：413
• 期：19-20
• 页码：1430-1437
• 全文大小：353 K

文摘

Background

The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance.

Methods

Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04 ¡À 0.82 y, BMI: 26.5 ¡À 1.2 kg/m²) participated in the study. All participants were housed together and their amount of physical activity (1823.5 ¡À 1.34 kcal/day) and food intake (1882 ¡À 68.8 kcal/day) were tightly controlled.

Results

Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r = ? .336, p = 0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = ? .334, p = 0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r = ? .280, p = 0.035) and HOMA-IR (r = ? .281, p = .034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: ? 2.33 ¡À 1.3 vs ? 1.46 ¡À 0.70, p = 0.004).

Conclusion

PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.