Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation
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- 作者：Tze-Chien Chen<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>1sup> ; Ming-Chih Yu<sup>csup><sup> ; sup><sup>dsup><sup> ; sup><sup>1sup> ; Chih-Chiang Chien<sup>esup><sup> ; sup><sup>fsup> ; Ming-Shun Wu<sup>gsup> ; Yu-Chieh Lee<sup>asup> ; Yen-Chou Chen<sup>asup><sup> ; sup><sup>hsup><sup> ; sup><sup>yc3270@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：AMN ; nilotinib ; BCIP ; 5-bromo-4-chloro-3-indolyl phosphate ; Bcl-2 ; B-cell lymphoma 2 ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; DMSO ; dimethyl sulfoxide ; EGF ; epidermal growth factor ; ELISA ; enzyme-linked immunosorbent assay ; ERK ; extracellular signal-regulated kinase ; H2O2 ; hydrogen peroxide ; JNK ; c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinase ; MMP ; mitochondrial membrane potential ; MTT ; 3-(4 ; 5 ; -dimethylthiazol)-2-yl-2 ; 5-diphenyltetrazolium bromide ; NAC ; N-acety
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：1-11
- 全文大小：2374 K
文摘
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Nilotinib induced apoptosis in various human ovarian cancer cells.
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Disrupted mitochondrial membrane potentiation leads to apoptosis by nilotinib.
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Increased intracellular peroxide and JNK by nilotinib
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NAC and JNK inhibitors did not inhibit apoptosis induced by nilotinib.
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A more potent cytotoxicity on ovarian cancer than non-cancerous cells by nilotinib