Tumor necrosis factor alpha ?238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes

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• 作者：Deep Dutta^a ; ^b ; ^{deepdutta2000@yahoo.com} ; Subhadip Choudhuri^a ; ^b ; ^{schoudhuri6@gmail.com} ; Samim Ali Mondal^a ; ^b ; ^{prot.samim@gmail.com} ; Indira Maisnam^a ; ^b ; ^{i.maisnam@gmail.com} ; Abu Hena Hasanoor Reza^a ; ^b ; ^{abu.rinku@rediffmail.com} ; Sujoy Ghosh^a ; ^b ; ^{drsujoyghosh2000@gmail.com} ; Subhankar Chowdhury^a ; ^b ; ^{subhankar.chowdhury@gmail.com} ; Basudev Bhattacharya^a ; ^b ; ^{bbasudev@rediffmail.com} ; Satinath Mukhopadhyay^a ; ^b ; ^{satinath.mukhopadhyay@gmail.com}
• 关键词：TNF¦Á &minus ; 238 G  ; &rarr ;   ; A polymorphism ; TNF¦Á &minus ; 308 G  ; &rarr ;   ; A polymorphism ; IL6 &minus ; 174 G  ; &rarr ;   ; C polymorphism ; Prediabetes ; Insulin resistance
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：99
• 期：3
• 页码：e37-e41
• 全文大小：326 K

文摘

Prediabetes (IPD; n = 122) and normoglycemic individuals (n = 100) underwent assessment of polymorphisms of TNF¦Á (?238, ?308) and IL6 (?174). After 27.25 ¡À 5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNF¦Á ?238AA/GA genotypes were significantly more common in IPD, had higher TNF¦Á, higher progression to diabetes and lower reversal.