Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India

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• 作者：Deep Dutta^a ; ^{deepdutta2000@yahoo.com" class="auth_mail} ; Samim Ali Mondal^b ; ^{prot.samim@gmail.com" class="auth_mail} ; Subhadip Choudhuri^b ; ^{schoudhuri6@gmail.com" class="auth_mail} ; Indira Maisnam^a ; ^{i.maisnam@gmail.com" class="auth_mail} ; Abu Hena Hasanoor Reza^b ; ^{abu.rinku@rediffmail.com" class="auth_mail} ; Basudeb Bhattacharya^b ; ^{bbasudev@rediffmail.com" class="auth_mail} ; Subhankar Chowdhury^a ; ^{subhankar.chowdhury@gmail.com" class="auth_mail} ; Satinath Mukhopadhyay^a ; ^{satinath.mukhopadhyay@gmail.com" class="auth_mail}
• 关键词：Vitamin-D ; Prediabetes ; Insulin resistance ; Systemic inflammation ; Diabetes
• 刊名：Diabetes Research and Clinical Practice
• 出版年：March, 2014
• 年：2014
• 卷：103
• 期：3
• 页码：e18-e23
• 全文大小：508 K

文摘

Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p = 0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p = 0.02), associated with decreased insulin resistance and systemic inflammation (TNF伪 and IL6). Baseline vitamin-D and 2 h blood glucose independently predicted progression to diabetes.