Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c
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- 作者：Jin-Sik Baea ; Ah-Reum Oha ; Ho-Jae Leea ; Yong-ho Ahnb ; Ji-Young Chaa ; c ; jycha1014@gachon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Elovl6 ; Carbohydrate ; ChREBP ; SREBP-1c ; Transcriptional regulation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1060-1066
- 全文大小：1388 K
文摘
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Elovl6 expression in response to refeeding is totally blunted in ChREBP–/– mice.
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ChREBP/Mlx overexpression increases mouse and human Elovl6 promoter activities.
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Direct binding of ChREBP/Mlx to ChoRE is dependent on feeding conditions.
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ChREBP and SREBP-1c synergistically activate Elovl6 promoter activity.