Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop

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• 作者：Gu Jing ; Junqin Chen ; Guanlan Xu ; Anath Shalev ; ^{shalev@uab.edu}
• 关键词：Carbohydrate response element binding protein ; Pancreatic islet ; Glucose-induced gene expression ; Transcription ; Diabetes
• 刊名：Molecular Metabolism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：12
• 页码：1208-1215
• 全文大小：622 K
• 卷排序：5

文摘

ChREBP-β is increased whereas expression of ChREBP-α is decreased in diabetes. ChREBP-β downregulates ChREBP-α via a negative feedback loop in islets. ChREBP-β thereby limits excessive glucose-induced ChREBP-α-mediated gene expression.