175 Is high sensitive C reactive protein related to clinical and echocardiographic risk of thrombo-embolism in patients with atrial fibrillation?

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• 作者：Afef Ben Halima¹ ; Manel Ben Halima² ; Nadia Hammami¹ ; Rym Chrigui¹ ; Salem Kachboura¹
• 刊名：Archives of Cardiovascular Diseases Supplements
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：3
• 期：1
• 页码：57
• 全文大小：49 K

文摘

Introduction

Atrial fibrillation is associated with a prothrombotic state with an increased risk of stroke. Recent studies suggested that there is an apparent link between thrombogeneses and inflammation.

Aim

we sought to study the relation between high sensitive C reactive protein (HS CRP) and clinical (CHAD score) and echocardiographic prothrombotic indexes in patients with atrial fibrillation.

Methods

we prospectively measured HS CRP in 100 patients with atrial fibrillation. The mean age was 56 ¡À 12 years. All patients underwent transoesophageal echocardiography (TEE). The TEE risk factors for thromboembolism considered were: a peak left appendage velocity 0.2 m/s, the presence of a thrombus and a dense spontaneous echo contrast.

Results

HS CRP was correlated with the clinical CHAD score (r = 0.54, p = 0.0001). CRP value was significantly higher among patients with a CHAD score 2 (6.91 ¡À 4.4 mg/dl vs 4.35 ¡À 3.8, p = 0.001). Values of HS CRP were comparable between patients having 1 TEE risk factor and those with no TEE risk factor (5.13 ¡À 3.7 vs 6.5 ¡À 0.5 p = NS).

Discussion and conclusion

the significant correlation between the CHAD score and HS CRP could be explained by the existence in this score of factors associated with elevated CRP. Although no apparent relation was found between the HS CRP and echocardiographic risk factors of thromboembolism, these results do not exclude the inflammatory hypotheses in the pathogeneses of thromboembolism. A study of the correlation between CRP and thrombo-embolic complications during follow up of patients is mandatory.