Serum sortilin-derived propeptides concentrations are decreased in major depressive disorder patients

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• 作者：Christelle Devader^a ; Morgane Roulot^a ; Sé ; bastien Moré ; no^a ; Alessandra Minelli^b ; Marco Bortolomasi^c ; Chiara Congiu^b ; Massimo Gennarelli^b ; ^d ; Marc Borsotto^a ; Catherine Heurteaux^a ; Jean Mazella^a ; ^{mazella@ipmc.cnrs.fr}
• 关键词：Sortilin ; Depression ; Propeptide ; Biomarker ; TREK-1 ; Diagnosis
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：443-447
• 全文大小：408 K
• 卷排序：208

文摘

Biomarkers to assess antidepressant treatment response are lacking. Serum level of sortilin-derived propeptide (PE) could be such a biomarker. Serum levels of PE are decreased in major depressive disorder patients. Serum levels of PE are recovered after antidepressive treatment. Dosing PE could assist psychiatrics in the diagnosis of antidepressant response.