SUVmax of ¹⁸FDG PET/CT as a predictor of high-risk endometrial cancer patients

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• 作者：Sofie Leisby Antonsen^a ; ^{sleisby@dadlnet.dk} ; Annika Loft^b ; Rune Fisker^c ; Anne Lerberg Nielsen^d ; Erik Sø ; gaard Andersen^e ; Estrid Hø ; gdall^f ; Ann Tabor^g ; ^k ; Kirsten Jochumsen^h ; Carsten L. Fagö ; -Olsen^a ; Jon Asmussenⁱ ; Anne Kiil Berthelsen^b ; Ib Jarle Christensen^j ; Claus Hø ; gdall^a
• 关键词：Endometrial cancer ; Maximum standardized uptake value (SUVmax) ; PET/CT ; Preoperative staging ; Risk-stratification
• 刊名：Gynecologic Oncology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：129
• 期：2
• 页码：298-303
• 全文大小：232 K

文摘

Objective

To evaluate SUVmax in the assessment of endometrial cancer preoperatively with particular focus on myometrial invasion (MI), cervical invasion (CI), FIGO stage, risk-stratification and lymph node metastases (LNM).

Methods

A total of 268 women with endometrial cancer or atypical endometrial hyperplasia underwent FDG PET/CT imaging before surgical treatment. SUVmax of the primary tumour was compared with histological prognostic factors.

Results

SUVmax was significantly higher in patients with high FIGO stages (p < 0.0001), deep MI (p = 0.002), CI (p = 0.04), LNM (p = 0.04) and high risk tumours (p = 0.003). Linear regression found that SUVmax was dependent of MI (p = 0.001, 95 % CI 2.863-11.098), CI (p = 0.001, 95 % CI 2.896-11.499), risk (p = 0.004, 95 % CI 0.077-0.397), LNM (p = 0.04, 95 % CI 0.011-0.482) and FIGO stage (p < 0.0001, 95 % CI 0.158-0.473).

Conclusions

Preoperative PET/CT scanning and SUVmax measurements of the primary tumour may provide additional clinical and prognostic information about MI, CI, LNM and high risk disease in patients with endometrial cancer and allow for individualization of patient care. However, the sensitivity and specificity of the SUVmax in staging endometrial cancer is not high enough to reliably replace surgical staging.