Maternal inheritance does not predict cholesterol levels in children with familial hypercholesterolemia
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- 作者：Ingunn Narveruda ; b ; Jeanine Roeters van Lennepc ; Jacob J. Christensena ; b ; Jorie Versmissenc ; Jon Michael Grand ; Per Ole Iversena ; e ; På ; l Aukrustf ; g ; h ; i ; l ; Bente Halvorsenf ; g ; i ; Thor Uelandf ; g ; i ; l ; Stine M. Ulvenj ; Leiv Osea ; b ; Marit B. Veierø ; da ; d ; Eric Sijbrandsc ; Kjetil Retterstø ; la ; b ; Kirsten B. Holvena ; k ; kirsten.holven@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Familial hypercholesterolemia ; Maternal inheritance ; LDL cholesterol ; Children
- 刊名：Atherosclerosis
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：243
- 期：1
- 页码：155-160
- 全文大小：439 K
文摘
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Only a few studies have investigated the effect of maternal hypercholesterolemia on plasma lipids.
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No differences in plasma levels of lipids in children with maternal compared to paternal FH.
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No differences in CRP levels in children with maternal compared to paternal FH.
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Children with LDL receptor negative mutations had higher total-and LDL cholesterol Maternal FH did not result in any detectable changes in offspring's lipid and CRP levels.
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Future research with a wider spectrum of inflammatory markers is required.