High level of transgene expression in primary chronic lymphocytic leukemia cells using helper-virus–free recombinant Epstein-Barr virus vectors

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• 作者：Wendtner ; Clemens-Martin ; Kurzeder ; Christian ; Theiss ; Hans D. ; Kofler ; David M. ; Baumert ; Jens ; et. al.
• 刊名：Experimental Hematology
• 出版年：2003
• 出版时间：February, 2003
• 年：2003
• 卷：31
• 期：2
• 页码：99-108
• 全文大小：196 K

文摘

Epstein-Barr virus (EBV)-based vectors have favorable features for gene transfer, including a high transduction efficiency especially for B cells, large packaging capacity up to 150 kb pairs, and ability to infect postmitotic cells. Recombinant EBV was explored for transduction of primary human B-cell chronic lymphocytic leukemia (CLL) cells.