The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: The SAPALDIA cohort

详细信息    查看全文

• 作者：Martin Adam^a ; ^b ; ¹ ; ^{martin.adam@unibas.ch} ; Medea Imboden^a ; ^b ; ¹ ; ^{medea.imboden@unibas.ch} ; Emmanuel Schaffner^a ; ^b ; ¹ ; ^{emmanuel.schaffner@unibas.ch} ; Eva Boes^a ; ^b ; ¹ ; Florian Kronenberg^c ; ¹ ; ^{florian.kronenberg@i-med.ac.at} ; Marco Pons^d ; ¹ ; ^{marco.pons@eoc.ch} ; Robert Bettschart^e ; ¹ ; ^{robert.bettschart@hin.ch} ; Jean-Claude Barthelemy^f ; ¹ ; ^{jc.barthelemy@univ-st-etienne.fr} ; Christian Schindler^a ; ^b ; ¹ ; ^{christian.schindler@unibas.ch} ; Nicole Probst-Hensch^a ; ^b ; ¹ ; ^{nicole.probst@unibas.ch}
• 关键词：Obesity ; Heart rate variability ; Autonomic nervous system ; Inflammation ; Polymorphism genetics
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：341-346
• 全文大小：385 K
• 卷排序：228

文摘

Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a genetic variation in a major anti-inflammatory marker gene, NFE2L2, on the relationship between overweight and HRV.MethodsWe analyzed participants of the SAPALDIA cohort aged 50 years and older, twice in 2002/2003 (N = 1472) and 2010/2011 (N = 1235). We included persons with valid genotype data, who underwent ambulatory 24-h electrocardiogram monitoring, and reported on medical history and lifestyle. The association between HRV and BMI, measured as standard deviation of normal-to-normal intervals (SDNN) by BMI and the modifying effect of the cardiovascular health-related NFE2L2 gene variant rs2364723 were tested, applying multivariable mixed linear regression models.ResultsWe found study participants with overweight (BMI > 25) over two follow-up surveys 10 years apart to have a negative association between SDNN, calculated as geometric means, with BMI. The examined NFE2L2 variant sustainably modified (pinteraction = 0.014) the found inverse association between a BMI increment and SDNN, causing a stronger decrement in SDNN for participants with the CC genotype (− 20.7%; 95%-confidence interval: − 12.33 to − 28.28) compared with participants carrying the GC (− 7.43; 95%CI: − 3.56 to − 11.15) or GG (− 11.26%; 95%CI: − 7.68 to − 14.7) genotype, estimated for the difference from the 90th to the 10th percentile of BMI by the NFE2L2 variant.ConclusionsOur results are consistent with the hypothesis that overweight decreases heart rate variability through inflammatory processes.