Low serum magnesium concentrations predict increase in left ventricular mass over 5 years independently of common cardiovascular risk factors

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• 作者：Thorsten Reffelmann ; Marcus Dö ; rr ; Till Ittermann ; Christian Schwahn ; Henry Vö ; lzke ; Jö ; rg Ruppert ; Daniel Robinson ; Stephan B. Felix
• 关键词：Magnesium ; Left ventricular mass ; Hypertrophy ; Epidemiology ; Arterial hypertension ; Blood pressure
• 刊名：Atherosclerosis
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：213
• 期：2
• 页码：563-569
• 全文大小：319 K

文摘

Objective

Left ventricular hypertrophy (LVH) is a significant predictor of adverse cardiovascular events. Experimental studies suggest a pathophysiological role of magnesium (Mg²⁺) in the development of arterial hypertension and LVH.

Methods

In subjects with complete echocardiographic data from the population-based longitudinal “Study of Health in Pomerania” (n = 1 348), the difference in left ventricular mass (LVM) over 5 years (echocardiography) was analyzed in relationship to serum Mg²⁺ at baseline.

Results

Mg²⁺ at baseline (0.790 ± 0.003 mmol/l, mean ± SEM) inversely correlated with the difference in LVM over 5 years (p < 0.0001, females: p < 0.002, males: p < 0.024). In the lowest Mg²⁺-quintile (Mg²⁺ <  = 0.73 mmol/l), LVM (187.4 ± 3.1 g at baseline) increased by 14.9 ± 1.2 g, while in the highest Mg²⁺-quintile (Mg²⁺ >  = 0.85 mmol/l) LVM (186.7 ± 3.4 g at baseline) decreased by −0.5 ± 2.8 g (p < 0.0001 between quintiles). By multivariable analysis including several cardiovascular risk factors and antihypertensive treatment, serum Mg²⁺ was associated with the increase in LVM at a statistically high significant level (p < 0.0001). LVM after 5 years was significantly higher in subjects within the lower Mg²⁺-quintiles. This association remained highly significant after adjustment for several cardiovascular risk factors including arterial hypertension and diabetes mellitus.

Conclusions

Hypomagnesemia is one of the strongest predictors of gain in LVM over the following 5 years.