Prospective Randomized Trial of Accelerated Re-epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

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• 作者：Christian Ottomann ; Bernd Hartmann ; Josh Tyler ; Heike Maier ; Richard Thiele ; Wolfgang Schaden ; Alex ; er Stojadinovic
• 刊名：Journal of the American College of Surgeons
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：211
• 期：3
• 页码：361-367
• 全文大小：448 K

文摘

Background

Extracorporeal shock wave therapy may enhance revascularization and repair of healing soft tissue.

Methods

Between January 2006, and September 2007, 28 patients with acute traumatic wounds and burns requiring skin grafting were randomly assigned in a 1:1 fashion to receive standard topical therapy (nonadherent silicone mesh [Mepitel, Mölnlycke Health Care] and antiseptic gel [polyhexanide/octenidine]) to graft donor sites with (n = 13) or without (n = 15) defocused extracorporeal shock wave therapy (ESWT, 100 impulses/cm² at 0.1 mJ/mm²) applied once to the donor site, immediately after skin harvest. The randomization sequence was computer generated, and the patients were blinded to treatment allocation. The primary endpoint was time to complete donor site epithelialization and was determined by an independent blinded observer.

Results

Statistical tests indicated no unbalanced distribution of subject characteristics across the two study groups. Mean times to complete graft donor site epithelialization for patients who did and did not undergo ESWT were 13.9 ± 2.0 days and 16.7 ± 2.0 days, respectively (p = 0.0001).

Conclusions

For centers that apply nonadherent gauze dressings and topical antiseptics to skin graft donor sites, application of a single defocused shock wave treatment immediately after skin graft harvest can significantly accelerate donor site epithelialization.