Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice
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- 作者：Marcus Boehmea ; 1 ; Madlen Guenthera ; 1 ; Anna Stahra ; b ; Marie Liebmanna ; c ; Nadine Jaenischa ; Otto W. Wittea ; d ; Christiane Frahma ; christiane.frahm@med.uni-jena.de" class="auth_mail
- 关键词：BrdU ; bromodeoxyuridine ; Cd68 ; cluster of differentiation 68 ; Cd86 ; cluster of differentiation 86 ; COX ; cyclooxygenase ; CTR ; control ; DCX ; doublecortin ; Gfap ; glial fibrillary acidic protein ; Iba1 ; ionized calcium-binding adaptor molecule 1 ; Il-1伪 ; interleukin 1伪 ; Il-1尾 ; interleukin 1尾 ; INDO ; indomethacin ; Lcn2 ; lipocalin 2 ; Mip-1伪 ; macrophage inflammatory protein 1伪 ; qPCR ; quantitative polymerase chain reaction ; Serpina3n ; serine (or cysteine) peptidase inhibitor ; clade A ; member 3N ; Tnf伪 ; tumo
- 刊名：Neuroscience Letters
- 出版年：20 June 2014
- 年：2014
- 卷：572
- 期：Complete
- 页码：7-12
- 全文大小：1003 K
文摘
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Effect of indomethacin on age-related neuroinflammation and neurogenesis was investigated in 24-month-old mice.
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Transcript expression of inflammatory mediators was upregulated in aged brains.
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Indomethacin decreased hippocampal COX-1 and COX-2 transcript expression.
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Gfap and Iba1 transcript expression were reduced by indomethacin in the aged hippocampus.
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Neurogenesis was unaffected by indomethacin.