No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes
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- 作者：Mette Soerensena ; b ; msoerensen@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Marianne Nygaarda ; b ; mnygaard@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Birgit Debrabanta ; bdebrabant@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Jonas Mengel-Froma ; b ; jmengel-from@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Serena Datoc ; s.dato@unical.it" class="auth_mail" title="E-mail the corresponding author ; Mikael Thinggaarda ; d ; mthinggaard@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Kaare Christensena ; b ; e ; kchristensen@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author ; Lene Christiansena ; lchristiansen@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human aging ; Oldest-old ; Single nucleotide polymorphisms ; Association study
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：57-61
- 全文大小：251 K
文摘
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No association of 125 longevity candidate genes to aging-related phenotypes.
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Previously the phenotypes were found to predict survival in the present cohort.
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Some of the genes were previously linked to longevity in the individuals studied.
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The lack of replication may be due to lack off power or age/cohort specific effects.