Effectiveness of 23-valent polysaccharide pneumococcal vaccine on pneumonia in HIV-infected adults in the United States, 1998–2003

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• 作者：Eyasu H. Teshale ; Debra Hanson ; Brendan Flannery ; Christina Phares ; Mitchell Wolfe ; Anne Schuchat ; Patrick Sullivan
• 关键词：Polysaccharide pneumococcal vaccine ; HIV-infected persons ; CD4 count ; HIV viral load
• 刊名：Vaccine
• 出版年：2008
• 出版时间：29 October 2008
• 年：2008
• 卷：26
• 期：46
• 页码：5830-5834
• 全文大小：162 K

文摘

Pneumococcal polysaccharide vaccine (PPV-23) has been recommended for HIV-infected adults. We investigated factors that could influence PPV-23 effectiveness against all-cause pneumonia in a longitudinal cohort of 23,255 HIV-infected adults receiving care during 1998–2003. Patients who received PPV-23 had a lower rate of pneumonia (IRR = 0.8; 95 % CI: 0.8–0.9) than patients who had never been vaccinated, independent of recent CD4 count, HIV viral load, antiretroviral therapy, and history of pneumonia. However, PPV-23 provided no benefit when patients were vaccinated at HIV viral load >100,000 copies/ml, irrespective of CD4 count at vaccination. Receipt of PPV-23 was associated with lower incidence of all-cause pneumonia.