- 作者：Ellen Hanson ; Sara Karlsson ; Katarina Jood ; Staffan Nilsson ; Christian Blomstr ; Christina Jern
- 关键词：SAHLSIS ; Sahlgrenska Academy Study on Ischemic Stroke ; TOAST ; Trial of Org 10172 in Acute Stroke Treatment ; MI ; myocardial infarction ; CAD ; coronary artery disease ; GWAS ; genome-wide association study ; SNP ; single-nucleotide polymorphism ; RFLP-PCR ; restri
- 刊名：Thrombosis Research
- 出版年：2012
- 出版时间：September, 2012
- 年：2012
- 卷：130
- 期：3
- 页码：339-342
- 全文大小：142 K
Introduction
The ABO blood group system is encoded by one gene, ABO. Previous studies have reported an association between blood group non-O (i.e. phenotype A, B or AB) and myocardial infarction. Studies on stroke and ABO are, however, more scarce. Therefore, we aimed to investigate whether ABO phenotype or genotype is associated with ischemic stroke and/or etiologic subtypes of ischemic stroke.Materials and methods
The study was performed in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), which comprises 600 patients with ischemic stroke before the age of 70 years, and 600 matched controls. Patients were classified according to the TOAST criteria.
Results
There was no significant association between ABO phenotype (blood group O vs. non-O) and overall ischemic stroke (multivariable odds ratio of 0.9, 95 % confidence interval 0.7-1.2). This was also true for blood group O vs. A and O vs. B. Furthermore, no association between ABO genotypes and ischemic stroke was detected. The ischemic stroke subtype analysis was confined to large-vessel disease, small-vessel disease, cardioembolic stroke and cryptogenic stroke. In this analysis, there was no significant association between any ischemic stroke subtype and ABO phenotype or genotype.
Conclusions
The findings in this study suggest that ABO phenotype or genotype does not have a major impact in the pathophysiology of ischemic stroke or any of the ischemic stroke subtypes.