Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling
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- 作者：Maia Limbacha ; 1 ; Mario Saarea ; 1 ; Liina Tserela ; 1 ; Kai Kisanda ; Triin Eglitb ; c ; Sascha Sauerd ; Tomas Axelssone ; Ann-Christine Syvä ; nene ; Andres Metspaluf ; Lili Milanif ; lili.milani@ut.ee" class="auth_mail" title="E-mail the corresponding author ; Pä ; rt Petersona ; part.peterson@ut.ee" class="auth_mail" title="E-mail the corresponding author
- 关键词：Graves' disease ; DNA methylation ; Epigenetics ; T cell signaling ; TSHR
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：46-56
- 全文大小：2024 K
文摘
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Genes involved in T cell activation and signaling show DNA hypermethylation in GD.
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Hypermethylated genes show reduced expression and H3K4me3/H3K27ac marks in GD.
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TSHR gene is hypermethylated and has lower levels of active histone marks in GD.