Neural functional organization of hallucinations in schizophrenia: Multisensory dissolution of pathological emergence in consciousness
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- 作者：Renaud Jardri ; Delphine Pins ; Maxime Bubrovszky ; Bernard Lucas ; Vianney Lethuc ; Christine Delmaire ; Vincent Vantyghem ; Pascal Despretz ; Pierre Thomas
- 关键词：Multisensory ; Hallucinations ; Schizophrenia ; Functional MRI ; Diffusion tensor imaging ; Cortical thickness ; sLORETA ; EEG ; Repetitive trans-cranial magnetic stimulation
- 刊名：Consciousness and Cognition
- 出版年：2009
- 出版时间：June 2009
- 年：2009
- 卷：18
- 期：2
- 页码：449-457
- 全文大小：361 K
文摘
Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.