Amino acid-catalyzed asymmetric α-amination of carbonyls

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• 作者：Christine Thomassigny ; Damien Prim and Christine Greck
• 关键词：Amination ; Organocatalysis ; Enantioselectivity ; l-Azetidine carboxylic acid ; Azodicarboxylates
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：13 February 2006
• 年：2006
• 卷：47
• 期：7
• 页码：1117-1119
• 全文大小：97 K

文摘

Electrophilic amination of ketones and aldehydes in the presence of dibenzylazodicarboxylate in dichloromethane, using l-azetidine carboxylic acid as a catalyst, is described. Yields and ee are discussed in comparison with the corresponding l-proline-catalyzed reaction.