Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

详细信息    查看全文

• 作者：Delphine Kalch ; Ramzi Ait Youcef ; Xavier Moreau ; Christine Thomassigny ; Christine Greck
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：27 September 2010
• 年：2010
• 卷：21
• 期：18
• 页码：2302-2306
• 全文大小：387 K

文摘

Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic α-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction.