Synthesis of chiral 1,2,3-triols via organocatalyzed ¦Á-hydroxylation of protected ¦Â-hydroxyaldehydes

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• 作者：Olivier Colin ; Philippe Hermange ; Christine Thomassigny ; Christine Greck ; ^{greck@chimie.uvsq.fr}
• 关键词：Hydroxylation ; Organocatalysis ; Enantioselectivity ; Hydroxyaldehydes ; 1 ; 2 ; 3-Triols
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：29 February, 2012
• 年：2012
• 卷：53
• 期：9
• 页码：1085-1088
• 全文大小：797 K

文摘

Protected 1,2,3-triols were prepared by organocatalytic ¦Á-hydroxylation of ¦Â-hydroxyaldehydes followed by in situ reduction. All diastereoisomers were obtained with correct yields and good to excellent de. The absolute configurations of the new asymmetric centers were confirmed by derivatization into the corresponding epoxide.