Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPAR????)

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• 作者：Bihan ; H??l??ne ; Rouault ; Christine ; Reach ; G??rard ; Poitout ; Vincent ; Staels ; Bart ; et. al.
• 关键词：Insulin secretion ; High-fat diet ; Fatty acid
• 刊名：FEBS Letters
• 出版年：2005
• 出版时间：April 25, 2005
• 年：2005
• 卷：579
• 期：11
• 页码：2284-2288
• 全文大小：238 K

文摘

This study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha (PPARα) influences insulin secretion. Freshly isolated islets of normoglycemic PPARα-null mice display no major alteration of glucose-stimulated insulin release. However, after 24 h of culture in high glucose, PPARα-null islets exhibit elevated basal insulin secretion and fail to increase insulin mRNA. 24-h culture with palmitate replicates this phenotype in wild-type islets. The data suggest that PPARα is needed to ensure appropriate insulin secretory response in situation of short-term hyperglycemia, likely by maintaining islet lipid homeostasis. As such, islet PPARα could contribute to delay the progression of type 2 diabetes.