Validity of abbreviated oral fat tolerance tests for assessing postprandial lipemia

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• 作者：Maria  ; Maraki^a ; Niki  ; Aggelopoulou^a ; Nektarios  ; Christodoulou^a ; Christina  ; Katsarou^a ; Panagiotis  ; Anapliotis^a ; Stavros A.  ; Kavouras^a ; Demosthenes  ; Panagiotakos^a ; Labros S.  ; Sidossis^a ;   ; ^b ;   ; ^{lasidoss@utmb.edu}
• 关键词：Triglyceride ; Lipid metabolism ; Clinical testing
• 刊名：Clinical Nutrition
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：30
• 期：6
• 页码：852-857
• 全文大小：291 K

文摘

Summary

Background & aims

Postprandial lipemia is assessed using the oral fat tolerance test (OFTT), a six-hour procedure requiring hourly blood sampling. In order to simplify the test, we investigated whether a)?a?single postprandial triacylglycerol concentration, b) an OFTT lasting less than six hours or c) an OFTT requiring fewer blood samples, may accurately assess postprandial lipemia under various conditions.

Methods

Seventy-two subjects underwent a conventional OFTT. Predictability of single-point concentrations and time-shortened tests was assessed using linear regression and re-sampling analysis. Validity of reduced-sampling tests was assessed using Pearson¡¯s correlation coefficients and Bland-Altman analysis.

Results

a) A single-point triacylglycerol concentration (3 or 4 h postprandially) did not present significant correlation with postprandial lipemia in the hypetriacylglycerolemic, exercise and energy restriction groups (P > 0.05), b) Time-shortened OFTT (4 h) was able to predict postprandial lipemia in every group studied (R² = 0.707?.970, P < 0.01), except the hypertriacylglycerolemics (P = 0.338), c) Reduced-sampling OFTT (3 or 4 samples) was able to assess postprandial lipemia in every group as well as in the overall sample (r = 0.874-0.997, P < 0.05).

Conclusions

A more convenient, reduced-sampling OFTT may be used alternatively to the conventional OFTT, whereas a time-shortened OFTT may be appropriate only for healthy people.