Arsenic-induced APL differentiation in cerebrospinal fluid

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• 作者：Annett Helwig ; Matthias Klemm ; Reinhard Schü ; ttig ; Christoph Rö ; llig ; Nasstasja Wassilew ; Gerhard Ehninger ; Thomas Illmer
• 关键词：APL ; Cerebrospinal fluid ; Treatment ; Arsenic trioxide
• 刊名：Leukemia Research
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：31
• 期：5
• 页码：703-705
• 全文大小：383 K

文摘

Although new approaches have dramatically improved, the treatment of acute promyelocytic leukemia (APL) involvement of the central nervous system (CNS) confers a bad prognosis in the disease. Here, we report a patient who was diagnosed with relapsed APL preferentially involving the CNS. Treatment with arsenic trioxide led to impressive morphological changes in CNS cellularity consistent with the induction of a differentiation syndrome. Since arsenic trioxide could be identified in the CNS, we provide evidence that the drug can cross the blood-brain barrier and can be used for treatment of extramedullary APL.