- 作者：Nicola Grossheinrich ; Anne Rau ; Oliver Pogarell ; Kristina Hennig-Fast ; Maren Reinl ; Susanne Karch ; Alica Dieler ; Gregor Leicht ; Christoph Mulert ; Andrea Sterr ; Frank Padberg
- 关键词：cTBS ; dorsolateral prefrontal cortex (DLPFC) ; iTBS ; medial prefrontal cortex (mPFC) ; repetitive transcranial magnetic stimulation (rTMS) ; treatment ; standardized low resolution brain electromagnetic tomography (sLORETA)
- 刊名：Biological Psychiatry
- 出版年：2009
- 出版时间：1 May 2009
- 年：2009
- 卷：65
- 期：9
- 页码：778-784
- 全文大小：535 K
Background
Because standard repetitive transcranial magnetic stimulation (rTMS) protocols exhibit post-stimulus effects of short duration, novel protocols such as theta burst stimulation (TBS), are promising approaches to enhance the effectiveness of rTMS. However, little is known about the side effect profile of such protocols. Thus, the present study explores whether TBS is safe particularly in terms of effects on cognition, mood, and electroencephalogram (EEG) measures in healthy subjects.Methods
Twenty-four healthy volunteers participated in 2 randomized, placebo-controlled, cross-over experiments and underwent continuous TBS (cTBS), intermittent TBS (iTBS), and shamTBS either over the left dorsolateral prefrontal cortex (DLPFC, n = 12) or the medial prefrontal cortices (mPFC, n = 12). Clinical side effects, performance in a neuropsychological battery, mood changes, and resting EEG were recorded.
Results
Neither a seizure nor epileptiform EEG activity was observed. The most prominent side effect was the occurrence of vagal reactions during TBS; otherwise no serious side effects were found. Standardized low-resolution brain electromagnetic tomography showed current density changes in the α2 band after iTBS of the DLPFC, which remained detectable up to 50 min after stimulation. The few changes in neuropsychological performance were concordant with stimulation site. No impact on mood was detected.
Conclusions
Although TBS protocols of the human prefrontal cortex seem to be safe in healthy subjects, future studies need to address the occurrence of vagal reactions. Excitatory and inhibitory properties of motor cortex TBS might not be transferable to prefrontal sites, and the action of specific TBS protocols needs to be further investigated prior to clinical application.