Lipoprotein (a) is independently correlated with coronary artery calcification

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• 作者：Martin Greif^a ; Thomas Arnoldt^a ; Franz von Ziegler^a ; Janine Ruemmler^a ; Christoph Becker^b ; Reza Wakili^a ; Melvin D'Anastasi^b ; Jan Schenzle^a ; Alexander W. Leber^c ; Alexander Becker^a ; ^{alexander.becker@med.uni-muenchen.de}
• 关键词：Lp(a) ; Lipoprotein a ; CAC ; Coronary artery calcification ; MCT ; Multislice CT ; CHD ; Coronary heart disease ; CVD ; Cardiovascular disease ; CT ; Computed tomography ; SD ; Standard deviation
• 刊名：European Journal of Internal Medicine
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：24
• 期：1
• 页码：75-79
• 全文大小：212 K

文摘

Introduction

Lipoprotein a (Lp(a)) has been recognized as a risk factor for both coronary heart diseases and for cardiovascular events. Coronary artery calcification (CAC) is a well proven marker for coronary artery disease and risk factor for cardiovascular events. Still there are conflicting data regarding the relationship of Lp(a) and CAC. We therefore wanted to evaluate the influence of Lp(a) on CAC.

Methods

1560 European patients (1123 men, age 59.3 ¡À 20.8 years) with typical or atypical chest pain underwent CAC scoring by a multi-slice CT-scanner, using a standard protocol. Blood samples were evaluated the same day using an automated particle enhanced immunoturbidimetric assay to determine Lp(a) serum levels.

Results

There was a positive correlation between CAC score, age, and common cardiovascular risk factors. Lp(a) serum levels were not associated with age but a positive correlation between Lp(a) serum levels and CAC was found. In the multivariate analysis age, diabetes, statin therapy, and Lp(a) could be identified as independent risk factors for CAC. (p < 0.001).

BMI, smoking, hypertension and LDL-C were not independently associated with CAC.

Conclusion

Lp (a) could be identified as an independent predictor of CAC, a marker of coronary atherosclerosis. Further a positive correlation between increasing Lp (a) levels and CAC scores was found.