The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
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- 作者：Kristin M. Jungea ; b ; kristin.junge@ufz.de" class="auth_mail ; Friederike Hö ; rniga ; friederike.hoernig@ufz.de" class="auth_mail ; Gunda Herbertha ; gunda.herberth@ufz.de" class="auth_mail ; Stefan Rö ; derc ; stefan.roeder@ufz.de" class="auth_mail ; Tibor Kohajdad ; tibor.kohajda@ufz.de" class="auth_mail ; Ulrike Rolle-Kampczykd ; e ; ulrike.rolle-kampczyk@ufz.de" class="auth_mail ; Martin von Bergend ; e ; f ; martin.vonbergen@ufz.de" class="auth_mail ; Michael Borteg ; Michael.Borte@sanktgeorg.de" class="auth_mail ; Jan-Christoph Simonh ; Jan-Christoph.Simon@medizin.uni-leipzig.de" class="auth_mail ; Delia Herouxb ; herouxd@mcmaster.ca" class="auth_mail ; Judah A. Denburgb ; denburg@mcmaster.ca" class="auth_mail ; Irina Lehmanna ; irina.lehmann@ufz.de" class="auth_mail
- 关键词：Cb ; cord blood ; CFU ; colony forming units ; Eo/B ; eosinophil/basophil ; ETS ; environmental tobacco smoke ; FHA ; family history of atopy ; GM-CSF ; granulocyte macrophage colony-stimulating factor ; IL-3 ; IL-5 ; interleukin 3 ; interleukin 5 ; IL-5R伪 ; interleukin 5 receptor alpha sub-unit ; VOC ; volatile organic compounds ; OR ; odds ratio ; Th2 ; T helper cell type 2.
- 刊名：Clinical Immunology
- 出版年：May-June 2014
- 年：2014
- 卷：152
- 期：1-2
- 页码：68-76
- 全文大小：651 K
文摘
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Predictive value of eosinophil/basophil (Eo/B) progenitor numbers at birth was studied.
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Higher numbers of cord blood Eo/B progenitor cells predict respiratory outcomes later in life.
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Tobacco smoke related benzene exposure supports the activation of these progenitors.
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A Th2 immune status at birth further contributes to higher cord blood Eo/B numbers.