Incidence of Acute Postoperative Endophthalmitis after Cataract Surgery: A Nationwide Study in France from 2005 to 2014

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• 作者：Catherine Creuzot-Garcher ; MD ; PhD¹ ; ² ; ^{catherine.creuzot-garcher@chu-dijon.fr" class="auth_mail" title="E-mail the corresponding author} ; Eric Benzenine ; PhD³ ; ⁴ ; ⁵ ; Anne-Sophie Mariet ; MD³ ; ⁴ ; ⁵ ; ⁸ ; ⁹ ; ¹⁰ ; Auré ; lie de Lazzer ; MD¹ ; Christophe Chiquet ; MD ; PhD⁶ ; ⁷ ; Alain M. Bron ; MD¹ ; ² ; Catherine Quantin ; MD ; PhD³ ; ⁴ ; ⁵ ; ⁸ ; ⁹ ; ¹⁰
• 关键词：CCAM ; Classification Commune des Actes Mé ; dicaux ; IRR ; incidence rate ratio ; PMSI ; Programme Mé ; dicalisé ; des Systè ; mes d&rsquo ; Information ; POE ; postoperative endophthalmitis
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：123
• 期：7
• 页码：1414-1420
• 全文大小：811 K

文摘

To report the incidence of acute postoperative endophthalmitis (POE) after cataract surgery from 2005 to 2014 in France.

Design

Cohort study.

Participants

Patients undergoing operation for cataract surgery by phacoemulsification and presenting acute POE.

Methods

We identified acute POE occurring within 6 weeks after phacoemulsification cataract surgery and the use of intracameral antibiotic injection during the surgical procedure by means of billing codes from a national database.

Main Outcome Measures

Incidence of acute POE.

Results

From January 2005 to December 2014, 6 371 242 eyes in 3 983 525 patients underwent phacoemulsification cataract surgery. The incidence of acute POE after phacoemulsification decreased from 0.145% to 0.053% during this 10-year period; the unadjusted incidence rate ratio (IRR) (95% confidence interval) was 0.37 (0.32–0.42; P < 0.001). In multivariate analysis, intracameral antibiotic injection was associated with a lower risk of acute POE 0.53 (0.50–0.57; P < 0.001), whereas intraoperative posterior capsule rupture, combined surgery, and gender (male) were associated with a higher risk of acute POE: 5.24 (4.11–6.68), 1.77 (1.53–2.05), and 1.48 (1.40–1.56) (P < 0.001), respectively.

Conclusions

Access to a national database allowed us to observe a decrease in acute POE after phacoemulsification cataract surgery from 2005 to 2014. Within the same period, the use of intracameral antibiotics during the surgical procedures increased.