Synthesis, reactivity and biological evaluation of novel halogenated tripentones

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• 作者：Vittoria Perri ; Christophe Rochais ; Thierry Cresteil ; Patrick Dallemagne ; Sylvain Rault
• 关键词：Tripentones ; Metallo-catalysed cross coupling ; Fused-ring systems
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2009
• 出版时间：15 November 2009
• 年：2009
• 卷：17
• 期：22
• 页码：7783-7788
• 全文大小：556 K

文摘

We describe herein the synthesis and the biological evaluation of a novel series of a potent anticancer agents: the tripentones. For the first time, a halogen atom was introduced in high yields on the pyrrole ring of the tricycle. This synthesis and the reactivity of the novel halogenated tripentones in metallo-catalysed cross-coupling reactions will be described in that article. Finally their influence on biological activity will be discussed.