Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy

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• 作者：Christopher S. Fry¹ ; ⁵ ; Tyler J. Kirby² ; ³ ; ⁵ ; Kate Kosmac³ ; ⁴ ; John J. McCarthy² ; ³ ; ^{jjmcca2@uky.edu} ; Charlotte A. Peterson² ; ³ ; ⁴ ; ⁶ ; ^{cpete4@uky.edu}
• 关键词：muscle ; hypertrophy ; satellite cells ; fibrosis ; microRNA ; muscle progenitor cells ; extracellular matrix ; collagen ; exosomes ; Pax7
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：56-69
• 全文大小：3954 K
• 卷排序：20

文摘

Myogenic progenitor cells (MPCs) regulate the muscle extracellular matrix MPCs regulate skeletal muscle fiber hypertrophy independent of fusion miR-206 in MPC exosomes regulates fibrogenic cell Rrbp1 and collagen expression MPCs regulate ECM remodeling within 1 week to facilitate fiber growth