Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice
Stress and HFHF diet alter adaptive immune responses in hippocampus and liver. Stress and HFHF diet increase insulin and cholesterol plasma levels. Lcn2 may play a key role in the systemic and hippocampal response in obesity. Biliverdin is impacted by HFHF and stress in the context of insulin alterations.