Plan quality and dosimetric association of patient-reported rectal and urinary toxicities for prostate stereotactic body radiotherapy

详细信息    查看全文

• 作者：X. Sharon Qi ; ^{xqi@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author} ; Jason P. Wang ; Caitlin L. Gomez ; Weber Shao ; Xiaoqing Xu ; Christopher King ; Daniel A. Low ; Michael Steinberg ; Patrick Kupelian
• 关键词：Prostate cancer ; Stereotactic body radiotherapy (SBRT) ; Plans quality ; Quality-of-life (QOL) ; Minimally clinically important difference (MID)
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：121
• 期：1
• 页码：113-117
• 全文大小：874 K

文摘

To study the association between dosimetric parameters with patient-reported quality-of-life (QOL) in urinary irritative/incontinency and bowel functions for prostate stereotactic body radiotherapy (SBRT).

Material and methods

The patient-reported QOL was evaluated using the Expanded Prostate Cancer Index Composite (EPIC-26). According to the progression in QOL score over 12 months, patients were assigned to one of three subgroups: score decrement, no change, or increment. The dosimetric parameters were cross-compared among subgroups in urinary and bowel domains using univariate Analysis of Variance (ANOVA). The evaluated dosimetric metrics included target volume, V100 (volume receiving 100% prescription dose); rectal volume/dose–volume endpoints, maximum/mean doses; bladder volume/dose–volume endpoints, and maximum/mean doses.

Results

Patients with consistent QOL reduction in urinary irritation function were significantly associated with greater mean bladder dose, greater V85/V90/V95/V100 and D_2cc/D_10cc. Patients with QOL reduction in urinary incontinence were marginally associated with greater mean bladder dose (p = 0.06). None of the evaluated dosimetric parameters showed a significant correlation with QOL score change in bowel function.

Conclusions

Patients with large prostate size were more susceptible to QOL decrements for urinary irritative and incontinency functions. Large bladder V85/V90/V95/V100 was associated with QOL decrements in the urinary irritative domain at 1-year after prostate SBRT.