Serendipity and VZV drug discovery

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• 作者：Marco Derudas ; ^{derudasm@cardiff.ac.uk} ; Christopher McGuigan
• 刊名：Drug Discovery Today: Technologies
• 出版年：2012
• 出版时间：Autumn, 2012
• 年：2012
• 卷：9
• 期：3
• 页码：e177-e181
• 全文大小：223 K

文摘

The discovery of drugs by chance (serendipity) has lead to the development of extremely important drugs in different fields, such as antibiotics, antitumoral and antipsychotic agents to name only a few examples. Recently, serendipity led to the discovery of a new category of compounds extremely active versus chickenpox-shingles (VZV) infections. The lead compound has been further developed and currently has successfully finished phase II clinical trials.