Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota
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- 作者：Feng Wang1 ; 14 ; Jess L. Kaplan2 ; 14 ; Benjamin D. Gold3 ; Manoj K. Bhasin4 ; Naomi L. Ward5 ; Richard Kellermayer6 ; Barbara S. Kirschner7 ; Melvin B. Heyman8 ; Scot E. Dowd9 ; Stephen B. Cox9 ; Haluk Dogan10 ; Blaire Steven5 ; George D. Ferry6 ; Stanley A. Cohen3 ; Robert N. Baldassano11 ; Christopher J. Moran2 ; Elizabeth A. Garnett8 ; Lauren Drake2 ; Hasan H. Otu10 ; Leonid A. Mirny12 ; Towia A. Libermann4 ; Harland S. Winter2 ; 15 ; hwinter@partners.org" class="auth_mail" title="E-mail the corresponding author ; Kirill S. Korolev1 ; 13 ; 15 ; korolev@bu.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：945-955
- 全文大小：1995 K
文摘
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Mutual information distinguishes Crohn disease and controls by using the microbiome
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Stool and ileal microbiomes contain the same information about Crohn disease
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Microbes more abundant in ileum than in stool positively correlate with Crohn disease
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Statistical power to detect association varies greatly among commonly used methods