Fatal and Near-Fatal Asthma in Children: The Critical Care Perspective

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• 作者：Christopher J.L. Newth ; MD ; FRCPC¹ ; ^{cnewth@chla.usc.edu} ; Kathleen L. Meert ; MD² ; Amy E. Clark ; MS³ ; Frank W. Moler ; MD⁴ ; Athena F. Zuppa ; MD⁵ ; Robert A. Berg ; MD⁵ ; Murray M. Pollack ; MD⁶ ; Katherine A. Sward ; PhD ; RN⁷ ; John T. Berger ; MD⁸ ; David L. Wessel ; MD⁸ ; Rick E. Harrison ; MD⁹ ; Jean Reardon ; BSN ; RN⁸ ; Joseph A. Carcillo ; MD¹⁰ ; Thomas P. Shanley ; MD⁴ ; Richard Holubkov ; PhD³ ; J. Michael Dean ; MD³ ; Allan Doctor ; MD¹¹ ; Carol E. Nicholson ; MD¹² ; Eunice Kennedy Shriver National Institute of Child Health ; Human Development Collaborative Pediatric Critical Care Research Network &lowast
• 关键词：CPCCRN ; Collaborative Pediatric Critical Care Research Network ; ECMO ; Extracorporeal membrane oxygenation ; ED ; Emergency department ; IV ; Intravenous ; LMV ; Length of mechanical ventilation ; NIH ; National Institutes of Health ; PICU ; Pediatric intensive care
• 刊名：The Journal of Pediatrics
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：161
• 期：2
• 页码：214-221.e3
• 全文大小：192 K

文摘

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Objective

To characterize the clinical course, therapies, and outcomes of children with fatal and near-fatal asthma admitted to pediatric intensive care units (PICUs).

Study design

This was a retrospective chart abstraction across the 8 tertiary care PICUs of the Collaborative Pediatric Critical Care Research Network (CPCCRN). Inclusion criteria were children (aged 1-18 years) admitted between 2005 and 2009 (inclusive) for asthma who received ventilation (near-fatal) or died (fatal). Data collected included medications, ventilator strategies, concomitant therapies, demographic information, and risk variables.

Results

Of the 261 eligible children, 33 (13 % ) had no previous history of asthma, 218 (84 % ) survived with no known complications, and 32 (12 % ) had complications. Eleven (4 % ) died, 10 of whom had experienced cardiac arrest before admission. Patients intubated outside the PICU had a shorter duration of ventilation (median, 25 hours vs 84 hours; P < .001). African-Americans were disproportionately represented among the intubated children and had a shorter duration of intubation. Barotrauma occurred in 15 children (6 % ) before admission. Pharmacologic therapy was highly variable, with similar outcomes.

Conclusion

Of the children ventilated in the CPCCRN PICUs, 96 % survived to hospital discharge. Most of the children who died experienced cardiac arrest before admission. Intubation outside the PICU was correlated with shorter duration of ventilation. Complications of barotrauma and neuromyopathy were uncommon. Practice patterns varied widely among the CPCCRN sites.