Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB
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- 作者：Matthew A. Gray1 ; Christopher H. Choy1 ; 2 ; Roya M. Dayam1 ; 2 ; Erika Ospina-Escobar1 ; 2 ; Alexander Somerville1 ; Xuan Xiao1 ; Shawn M. Ferguson3 ; Roberto J. Botelho1 ; 2 ; rbotelho@ryerson.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fc receptors ; endocytosis ; phagocytosis ; macrophages ; gene expression ; lysosomes
- 刊名：Current Biology
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：26
- 期：15
- 页码：1955-1964
- 全文大小：2783 K
文摘
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Engagement of phagocytic receptors enhances lysosomal and bactericidal activity
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The transcription factor TFEB is required to boost lysosome degradation and killing
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TFEB activation requires phagosome completion
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TFEB activation requires release of lysosome Ca2+ during phagosome maturation