Total synthesis of the polyene macrolide dermostatin A

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• 作者：Sinz ; Christopher J. ; Rychnovsky ; Scott D.
• 关键词：cyanohydrin alkylation ; polyene macrolide ; Stille coupling
• 刊名：Tetrahedron
• 出版年：2002
• 出版时间：August 5, 2002
• 年：2002
• 卷：58
• 期：32
• 页码：6561-6576
• 全文大小：569 K

文摘

Herein we provide full details of studies which culminated in the first total synthesis of the polyene macrolide dermostatin A, confirming our earlier stereochemical assignment. A highly convergent synthesis was developed, featuring the cyanohydrin acetonide method for polyol construction and a Stille approach to polyene introduction. The strategies and tactics developed en route should be of value for the preparation of other members of the polyene macrolide class, as well as analogs of the dermostatins.