The positive transcriptional elongation factor (P-TEFb) is required for neural crest specification
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- 作者：Victoria L. Hatcha ; 1 ; Marta Marin-Barbaa ; Simon Moxona ; 2 ; Christopher T. Forda ; Nicole J. Warda ; Matthew L. Tomlinsona ; Ines Desanlisa ; Adam E. Hendrya ; Saartje Hontelezb ; Ila van Kruijsbergenb ; Gert Jan C. Veenstrab ; Andrea E. Mü ; nsterberga ; Grant N. Wheelera ; grant.wheeler@uea.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neural crest cells ; Leflunomide ; Transcriptional elongation ; c-Myc ; P-TEFb ; Xenopus ; Polymerase pausing ; Cdk9 ; CyclinT1
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：416
- 期：2
- 页码：361-372
- 全文大小：3138 K
文摘
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Leflunomide inhibits neural crest specification.
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Knockdown of P-TEFb components Cdk9 or CyclinT1 inhibits neural crest specification.
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c-Myc can rescue the effect of leflunomide and knockdown of P-TEFb.
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c-Myc is a ‘paused’ gene during development.
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c-Myc is a ‘gate-keeper’ for the correct development of the neural crest.