Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

详细信息    查看全文

• 作者：Kaberi P. Das^a ; Carmen R. Wood^a ; Mimi T. Lin^a ; Anatoly A. Starkov^b ; Christopher Lau^a ; Kendall B. Wallace^b ; J. Christopher Corton^c ; Barbara D. Abbott^a ; ^{abbott.barbara@epa.gov}
• 关键词：PFAAs ; Perfluoroalkyl acids ; PFOS ; perfluorooctane sulfonate ; PFOA ; perfluorooctanoic acid ; PFNA ; perfluorononanoic acid ; PFHxS ; perfluorohexane sulfonate ; TG ; triglycerides ; WY ; Wyeth 14 ; 643 ; WT ; wild type ; Null ; PPARα-null ; GEO ; Gene Expression Omnibus ; PC ; palmitoylcarnitine ; CPT ; acylcarnitine transporter ; DNP ; 2 ; 4 ; -dinitrophenol ; C-228 ; surfactant mixture ; LPL ; lipoprotein lipase ; LDL ; Low density lipoprotein ; VLDL ; Very low density lipoprotein ; PPAR ; peroxisome proliferator-activated recep
• 刊名：Toxicology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：378
• 期：Complete
• 页码：37-52
• 全文大小：3906 K
• 卷排序：378

文摘

Structurally diverse PFAAs induced fatty liver and increased TG accumulation in mouse. Genes of lipid synthesis and degradation were increased after exposure to PFAAs. PFAAs did not inhibit either mitochondrial fatty acid transport or β-oxidation directly.