Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control
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- 作者：Soroush Tahmasebi1 ; 2 ; Tommy Alain8 ; Vinagolu K. Rajasekhar3 ; Jiang-Ping Zhang1 ; 4 ; Masha Prager-Khoutorsky5 ; Arkady Khoutorsky1 ; 2 ; Yildirim Dogan6 ; Christos G. Gkogkas9 ; Emmanuel Petroulakis1 ; 2 ; Annie Sylvestre1 ; 2 ; Mohammad Ghorbani1 ; 4 ; Sarah Assadian1 ; 2 ; Yojiro Yamanaka1 ; 7 ; Julia R. Vinagolu-Baur6 ; Jose G. Teodoro1 ; 2 ; Kitai Kim6 ; Xiang-Jiao Yang1 ; 2 ; 4 ; xiang-jiao.yang@mcgill.ca" class="auth_mail ; Nahum Sonenberg1 ; 2 ; 4 ; nahum.sonenberg@mcgill.ca" class="auth_mail
- 刊名：Cell Stem Cell
- 出版年：1 May 2014
- 年：2014
- 卷：14
- 期：5
- 页码：606-616
- 全文大小：2802 K
文摘
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eIF4E-dependent translation is inhibited in pluripotent iPSCs and ESCs
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4E-BPs are required for MEF reprogramming
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Lack of 4E-BP1 and 4E-BP2 in p53-null MEFs leads to better reprogramming
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Augmented translation of Sox2 and Myc mRNAs in TKO MEFs promotes reprogramming