Reduced Chrna7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABAA receptor subunits
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- 作者：R.C. Batesa ; b ; c ; B.J. Stithc ; K.E. Stevensa ; b ; C.E. Adamsa ; b ; cehelmke@gmail.com" class="auth_mail
- 关键词：5-HT3 ; serotonin 3 receptor ; BDNF ; brain-derived neurotrophic factor ; CHRNA7/Chrna7 ; gene (human/mouse) encoding the 伪7 nicotinic acetylcholine receptor ; CREB ; cAMP response element binding protein ; DLPFC ; dorsal lateral prefrontal cortex ; DTT ; dithiothreitol ; EDTA ; ethylenediaminetetraacetic acid ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; GABA ; 纬-aminobutyric acid ; GAD-65 ; l-glutamic acid decarboxylase-65 ; GAD-67 ; l-glutamic acid decarboxylase-67 ; Het ; heterozygous ; KO ; knockout ; mRNA
- 刊名：Neuroscience
- 出版年：25 July 2014
- 年：2014
- 卷：273
- 期：Complete
- 页码：52-64
- 全文大小：618 K
文摘
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Reduced Chrna7 expression is associated with increased hippocampal parvalbumin.
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Reduced Chrna7 expression is associated with increased hippocampal GAD67.
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Reduced Chrna7 expression alters hippocampal GABAA receptor subunit levels.