Concurrent estimation of metabolite concentrations along with parent drug quantification in post-mortem blood
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- 作者：Jenni Viinamä ; ki1 ; jenni.viinamaki@helsinki.fi" class="auth_mail" title="E-mail the corresponding author ; Ilkka Ojanperä ; 1 ; 2
- 关键词：Drug metabolite quantification ; Universal detection ; Corona charged aerosol detection ; Photodiode array detection ; Ultra-high performance liquid chromatography ; Post-mortem blood
- 刊名：Forensic Science International
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：267
- 期：Complete
- 页码：110-114
- 全文大小：246 K
文摘
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Method to estimate metabolite concentrations without reference standard is reported.
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UHPLC with photodiode array and corona charged aerosol detection was used.
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Metabolite calibration was performed concurrently based on parent drugs.
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Non-MS detection showed similar response to parent drugs and N-demethyl metabolites.
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Metabolite concentrations were retrieved from previously generated analytical data.