Chromatographic impurity fingerprinting of genuine and counterfeit Cialis® as a means to compare the discriminating ability of PDA and MS detection
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- 作者：D. Custersa ; b ; B. Krakowskac ; J.O. De Beera ; P. Coursellea ; M. Daszykowskic ; S. Apersb ; 1 ; E. Deconincka ; 1 ; Eric.Deconinck@wiv-isp.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Counterfeit medicines ; Cialis® ; Chemometrics ; High Performance Liquid Chromatography ; Photodiode array detection ; Mass spectrometry
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：540-548
- 全文大小：747 K
文摘
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PDA- and MS-fingerprints were tested for their discriminating properties.
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Fingerprints result in reliable distinction of genuine medicines from counterfeits.
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PDA fingerprints result in a perfect discrimination between genuine and counterfeit.
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MS fingerprints result in a perfect discrimination between genuine and counterfeit.
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When analysing a larger sample set sophisticated techniques, like MS, are necessary.