Polymorphism − 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population
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- 作者：Shengyuan Liua ; b ; Guoda Maa ; Songpo Yaoc ; Zhongwei Chenb ; Changyi Wangb ; Bin Zhaod ; zhaobine@163.net" class="auth_mail" title="E-mail the corresponding author ; Keshen Lia ; likeshen1971@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; T2D ; type 2 diabetes ; XBP1 ; X box binding protein 1 ; β ; pancreatic beta ; IR ; insulin resistance ; HDLC ; high-density lipoprotein cholesterol ; LDLC ; low-density lipoprotein cholesterol ; WHO ; World Health Organization ; BMI ; body mass index ; HPLC ; high pressure liquid chromatography ; HOMA ; homeostatic model assessment ; HWE ; Hardy&ndash ; Weinberg equilibrium ; CIs ; confidence intervals ; ORs ; odds ratios
- 刊名：Gene
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：575
- 期：1
- 页码：71-74
- 全文大小：221 K
文摘
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The − 116GG genotype and − 116G allele of XBP1 were more frequent in T2D subjects compared with control subjects.
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T2D subjects with 116GG genotype of XBP1 had higher fasting plasma glucose, fasting insulin, HbA1c and worse HOMA-IR.