ROS production and gene expression in alveolar macrophages exposed to PM2.5 from Baghdad, Iraq: Seasonal trends and impact of chemical composition
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- 作者：Samera H. Hamada ; 1 ; shamad@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; shamad@umd.edu" class="auth_mail" title="E-mail the corresponding author ; James J. Schauera ; b ; jjschauer@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Dagmara S. Antkiewiczb ; dksieprawska@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Martin M. Shafera ; b ; mmshafer@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Ahmed KH. Kadhimc ; ahmed_khudhair@ymail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AM ; alveolar macrophages ; CM ; crustal materials ; DCFH-DA ; 2&prime ; 7&prime ; -dichloro-dihydro-fluorescein diacetate ; EC ; elemental carbon ; GC/MS ; gas chromatography/mass spectrometry ; OC ; organic carbon ; PCA ; principle component analysis ; PM ; particulate matter ; PAHs ; polyaromatic hydrocarbons ; qRT-PCR ; quantitative real time-polymerase chain reaction ; ROS ; reactive oxygen species ; SF-ICP-MS ; sector field-inductively coupled plasma-mass spectrometry ; SI ; supporting information
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：543
- 期：part_PA
- 页码：739-745
- 全文大小：514 K
文摘
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Baghdad's PM2.5 analyzed for chemical content and toxicity
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Pro-inflammatory Cxcl1, Il1b, Tnfα, Ccl2 and Ccl7 were most highly upregulated.
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ROS correlated with PM mass, OC, levoglucosan, sulfur, PAHs, CM and metals
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Cytokine expression correlated with ROS, PM mass, CM and metals (Ni, Fe, V, Cr)
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The antioxidant genes (Nqo1 and Hmox1) correlated with Cu, Zn, PAHs and hopanes