The Joule-Thomson coefficient as a criterion for efficient operating conditions in supercritical fluid chromatography

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• 作者：Donald P. Poe^a ; ^{dpoe@d.umn.edu} ; Shawn Helmueller^a ; ¹ ; Stephanie Kobany^a ; ² ; Hannah Feldhacker^a ; Krzysztof Kaczmarski^b
• 关键词：Supercritical fluid chromatography ; Virtual fluid model ; Radial temperature gradients ; Efficiency maps ; Joule-Thomson coefficient ; Kinetic performance
• 刊名：Journal of Chromatography A
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：1482
• 期：Complete
• 页码：76-96
• 全文大小：1771 K
• 卷排序：1482

文摘

A virtual fluid model to estimate radial temperature gradients in SFC is proposed. The onset of efficiency loss occurs at a fixed value of the Joule-Thomson coefficient. The concept of efficiency maps in SFC is introduced. Superficially porous particles provide efficient separations at lower outlet pressures. Kinetic performance in SFC improves as temperature is increased.